趙崇義报告题目： G6PD-deficiency: A model to investigate the role of redox homeostasis in cell and in health
钱鉞报告题目 ：New Paradigm for Targeting COX-Catalyzed Free Radical Peroxidation in Colon Cancer
报 告 人：趙崇義教授、钱鉞教授
报告时间：4月27日（周一）下午14:00-16:30
报告地点：生物电子学国家重点实验室 三楼会议室
主 持：钱卫平教授
报告人简介：
DANIEL TSUN-YEE CHIU
Distinguished Professor, Dept. of Medical Biotechnology and Clinical
Laboratory Sciences, Chang Gung University, Taiwan
President, Society of Free Radical Research-Asia (2014-2015)
Editorial Board Member, Free Radical Research
AFFILIATIONS
1997-present Consultant, Dept. of Laboratory Medicine, Chang Gung Memorial Hosp.
Linkou, Taiwan
2006-present Dean of Research & Development, Chang Gung Univ., Taiwan
2009-present Distinguished Professor, Dept. of Medical Biotechnology & Clinical
Laboratory Sciences, Chang Gung Univ., Taiwan
2011-present Director, Healthy Aging Research Center, Chang Gung Univ., Taiwan
EDUCATION
1972 B.S., Biochemistry, University of California, Davis, CA, USA
1976 Ph.D., Biochemistry, University of California, Davis, CA, USA
1976-1980 Postdoctoral Fellow, Department of Hematology/Oncology, Children's Hosp.
Oakland Research Inst., Oakland, CA, USA
RESEARCH (Publications in 2011-2015)
1. Yang HC, Cheng ML, Ho HY, Chiu DTY* (2011) The microbicidal and cytoregulatory roles of NADPH
oxidases. Microbes and Infection 13:109-20 (SCI )
2. Chen KH, Cheng ML, Jing YH, Chiu DTY, Shiao MS, Chen JK (2011)Resveratrol ameliorates metabolic
disorders and muscle wasting in streptozotocin-induced diabetic rats. American Journal of Physiology -
Endocrinology and Metabolism 301: E853-E863.
3. Cheng ML, Shiao MS, Chiu DTY, Weng SF, Tang HY, Ho HY (2011)Biochemical disorders associated with
antiproliferative effect of dehydroepiandrosterone in hepatoma cells as revealed by LC-based metabolomics.
Biochem Pharmacol 82:1549-61(SCI )
4. Chen YC, Chen CM, Liu JL, Chen ST, Cheng ML, Chiu DTY*. (2011) Oxidative markers in spontaneous
intracerebral hemorrhage: leukocyte 8-hydroxy-2'-deoxyguanosine as an independent predictor of the 30-day
outcome. J Neurosurg 115:1184-90 (SCI )
5. Cheng ML, Ho HY, Shiao MS, Chiu DTY* (2013) Characterization of Global Metabolic Responses of G6PDDeficient
Hepatoma Cells to Diamide-Induced Oxidative Stress. Free Radic Biol Med. 54C:71-84 (SCI)
6. Yang HC, Chen TL, Wu YH, Cheng KP, Lin YH, Cheng ML, Ho HY, Lo SJ* and Chiu DTY*(2013) Glucose
6-phosphate dehydrogenase (G6PD) deficiency enhances germ cell apoptosis and causes defective
embryogenesis in Caenorhabditis elegans. Cell Death Dis. 4:e616. doi: 10.1038/cddis.2013.132 (SCI)
7. Lin HR, Wu CC, Wu YH, Hsu CW, Cheng ML, Chiu DTY* (2013) Proteome-wide dysregulation by
glucose-6-phosphate dehydrogenase reveals a novel protective role for G6PD in Aflatoxin B1-mediated
cytotoxicity. J Proteome Res 12: 3434-48(SCI)
8. Cheng ML, Ho HY, Lin HY, Lai YC, Chiu DTY* (2013) Effective NET formation in neutrophils from
individuals with G6PD Taiwan-Hakka is associated with enhanced NADP+ biosynthesis. Free Rad Research
47: 699-709(SCI)
9. Ho HY, Cheng ML, Chiu DTY*(2014) Glucose-6-phosphate dehydrogenase - beyond the realm of red cell
biology. Free Radical Research 48: 1028-48(SCI)
10. Chiu DTY (2014) Oxidative stress in biology and medicine (Editorial Note). Biomedical J 37:97-98
11. Chiu DTY, Wei YH (2014) Special issue on “Oxidative stress and mitochondrial alterations in ageing and
disease. (Editorial). Free Rad Research 48: 967-969(SCI)
12. Tang HY, Ho HY, Wu PR, Chen SH, Kuypers FA, Cheng ML, Chiu DTY* (2015) Inability to Maintain GSH
Pool in G6PD-Deficient Red Cells Causes Futile AMPK Activation and Irreversible Metabolic Disturbance.
Antioxid & Redox Sign. in press (SCI)
Steven Y. Qian, Ph. D.
Associate Professor, Department of Pharmaceutical Sciences, College of Pharmacy, Nursing, and Allied Sciences, North Dakota State University
Sudro Hall 208, NDSU Dept 2665, P.O. Box 6050, Fargo, ND 58108-6050
Phone: (701) 231-8511 Fax: (701) 231-8333 e-mail: steven.qian@udsu.edu
___________________________________________________________________________________________________
PROFESSIONAL EXPERIENCE
2012-date: Tenured Associate Professor, Department of Pharmaceutical Sciences, College of Pharmacy, Nursing, and Allied Sciences, North Dakota State University, Fargo, ND.
2012-date: Guest Researcher/Special Volunteer, Lab. Toxicology and Pharmacology, National Institute of Environmental Health Sciences (NIEHS/NIH), Research Triangle Park, NC NIEHS, NIH.
2006-date: Joint Faculty and Associate Professor, Cellular and Molecular Biology Program (CMB), North Dakota State University, Fargo, ND.
2008-date: Joint Faculty Member, Investigator, and Associate Professor, Center for Protease Research, North Dakota State University, Fargo, ND.
2005-2012: Assistant Professor, Department of Pharmaceutical Sciences, College of Pharmacy, Nursing, and Allied Sciences, North Dakota State University, Fargo, ND.
2004-2007: Guest Researcher/Special Volunteer, Lab. Pharmacology and Chemistry, National Institute of Environmental Health Sciences (NIEHS/NIH), Research Triangle Park, NC NIEHS, NIH
2004-2005: Research Assistant Professor, Division of Drug Delivery and Disposition, School of Pharmacy, The University of North Carolina at Chapel Hill, NC.
1999-2004: IRTA/Visiting Fellow, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC.
1994-1999: Graduate Research Assistant, Free Radical and Radiation Biology Program, College of Medicine, The University of Iowa, Iowa City, IA.
PROFESSIONAL HONORS
2014 President and Executive Secretary, International Chinese Society on Research of Free Radical Biology in Medicine
2014 Section Chair, 21st Annual Meeting of SFRBM
2014 Editorial Board, Free Radical Research
2014 SFRBM Junior Award Committee
2014 SFRBM Recruitment Committee and Junior Award Committee
2014 International Scientific Executive Committee of The 8th Pong Ding Yuen International Symposium on Traditional Chinese Medicine cum, The 2nd International Chinese Symposium on Free Radical Research & The 6th Symposium for Three Districts of Cross-straits on Free Radical Research
2013 Dean’s Award for Excellence in Service, College of Pharmacy, Nursing, and Allied Sciences, North Dakota State University
2013 Young Investigator and Travel Award Committee, 20th SFRBM
报告人从事自由基、衰老与癌症研究多年，对我院的实验研究应该具有很好的参考价值，欢迎感兴趣的老师和同学参加！
